Recombinant human Tif1 gamma (Trim33)
Full length recombinant human N-terminal Flag tagged TRIM33 (Tripartite Motif Containing 33) protein, produced in SF9 insect cells.
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Product Description
TRIM33 recombinant protein
Other names
TIF1G, TIF1gamma, TF1G, RFG7, ECTO, PTC7
Target description
TRIM33 (UniProt/Swiss-Prot entry Q9UPN9) is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. TRIM33 is an E3 ubiquitin-protein ligase, which promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. It may act as a transcriptional corepressor and inhibits the transcriptional response to the TGF-beta/BMP signaling cascade. However, molecules that interact with this protein have not yet been identified..TRIM33 also plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor. Defects in TRIM24 cause thyroid papillary carcinoma.
Concentration
0.5µg/µl
Specificity
Human
Purity
Purified using FPLC, >95% purity as determined by SDS-PAGE.
Storage Buffer
20mM Tris-Cl pH 7.6, 1 mM EDTA, 0.15 M NaCl, 10% glycerol, 0.5 mM PMSF and 1 mM DTT.
Storage
Store at-80°C; guaranteed stable for 2 years from date of receipt when stored properly.
Precautions: This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Quality Control
Figure 1.
SDS page of the TRIM33 recombinant protein. The position of the protein of interest is indicated on the right; the marker (in kDa) is shown on the left.
Documents
| TRIM33 recombinant protein DATASHEET Datasheet of TRIM33 recombinant protein | Download |
Publications
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