Recombinant human MBD4
Active full length recombinant human N-terminal His tagged MBD4 (Methyl-CpG Binding Domain Protein 4) protein, produced in SF9 insect cells.
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C23010101
Recombinant human Hp1 alpha (CBX5)
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C23010102
Recombinant human Hp1 beta (CBX1)
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C23010106
Recombinant human MeCp2
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C23010109
Recombinant human Tif1 alpha (Trim24)
Product Description
MBD4 recombinant protein
Other names
MED1
Target description
MBD4 (UniProt/Swiss-Prot entry O95243) belongs to the family of methyl CpG binding proteins that specifically bind to methylated CpG dinucleotides. MBD4 probably functions to mediate the biological consequences of CpG methylation. Further, MBD4 has thymine glycosylase activity and is involved in DNA mismatch repair. It is specific for G/T mismatches within methylated and unmethylated CpG sites Mutations of MBD4 are associated with tumors with primary microsatellite-instability, a type of genomic instability that is caused by a defective DNA mismatch repair.
Concentration
0.5µg/µl
Specificity
Human
Purity
Purified using FPLC, >95% purity as determined by SDS-PAGE.
Storage Buffer
20mM Tris-Cl pH 7.6, 1 mM EDTA, 0.15 M NaCl, 10% glycerol, 0.5 mM PMSF and 1 mM DTT.
Storage
Store at-80°C; guaranteed stable for 2 years from date of receipt when stored properly.
Precautions: This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Quality Control
Figure 1.
SDS page of the MBD4 recombinant protein. The position of the protein of interest is indicated on the right; the marker (in kDa) is shown on the left.
Documents
| MBD4 recombinant protein DATASHEET Datasheet of MBD4 recombinant protein | Download |
Publications
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