Recombinant Histone H3.3-H4 tetramers
Tetramer of 2 full length N-terminal Flag tagged recombinant histone H4 units and 2 N-terminal His tagged recombinant histone H3.3 units, produced in E. coli.
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C23010003
Recombinant Histone H3
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C23010001
Recombinant Histone H2A
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C23010013
Recombinant Histone H3.1 - H4 tetramers
Protein description
Histones are the main constituents of the protein part of chromosomes of eukaryotic cells. They are rich in the amino acids arginine and lysine and have been greatly conserved during evolution. Histones pack the DNA into tight masses of chromatin. Two core histones of each class H2A, H2B, H3 and H4 assemble and are wrapped by 146 base pairs of DNA to form one octameric nucleosome. Histone tails undergo numerous post-translational modifications, which either directly or indirectly alter chromatin structure to facilitate transcriptional activation or repression or other nuclear processes. The histone variant H3.3 replaces conventional H3.1 in a wide range of nucleosomes in active genes. H3.3 constitutes the predominant form of histone H3 in non-dividing cells.
Quality control
Figure 1.
SDS page of the Recombinant Histone H3.3-H4 tetramers. The position of the protein of interest is indicated on the right; the marker (in kDa) is shown on the left.
Figure 2.
ESi-TOF analysis of the Recombinant Histone H3.3-H4 tetramers.
Documents
| C23010014 histone H3-3 DATASHEET C23010014 histone H3-3 tds | Download |
Publications
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