Recombinant Histone H2A.Z-H2B dimers
Dimer of full length N-terminal Flag tagged recombinant histone H2A.Z and N-terminal His tagged recombinant histone H2B, produced in E. coli.
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C23010003
Recombinant Histone H3
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C23010001
Recombinant Histone H2A
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C23010014
Recombinant Histone H3.3-H4 tetramers
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C23010013
Recombinant Histone H3.1 - H4 tetramers
Protein description
Histones are the main constituents of the protein part of chromosomes of eukaryotic cells. They are rich in the amino acids arginine and lysine and have been greatly conserved during evolution. Histones pack the DNA into tight masses of chromatin. Two core histones of each class H2A, H2B, H3 and H4 assemble and are wrapped by 146 base pairs of DNA to form one octameric nucleosome. Histone tails undergo numerous post-translational modifications, which either directly or indirectly alter chromatin structure to facilitate transcriptional activation or repression or other nuclear processes. The histone variant H2A.Z replaces conventional H2A in a subset of nucleosomes. H2A.Z is involved in transcriptional regulation, antisilencing, silencing, and genome stability. It functions as a key regulator of chromatin function and plays an essential role during mammalian development.
Quality control
Figure 1.
SDS page of the Recombinant Histone H2A.Z-H2B dimers. The position of the proteins of interest is indicated on the right; the marker (in kDa) is shown on the left.
Figure 2.
ESi-TOF analysis of the Recombinant Histone H2A.Z-H2B dimers.
Documents
| C23010012 histone H2AZ-H2B DATASHEET C23010012 histone H2AZ-H2B tds | Download |
Publications
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