Recombinant Histone H2A.X
Full length recombinant histone H2A.X, produced in E. coli.
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C23010003Recombinant Histone H3
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C23010004
Recombinant Histone H4
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C23010001
Recombinant Histone H2A
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C23010002
Recombinant Histone H2B
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C23010006
Recombinant Histone H2A.Z
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C23010014
Recombinant Histone H3.3-H4 tetramers
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C23010012
Recombinant Histone H2A.Z-H2B dimers
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C23010008
Recombinant Histone H3.3
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C23010016
Recombinant H3.1 Core Histone
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C23010017
Recombinant H3.3 Core Histone
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C23010009
Recombinant Histone H3.3 K27M
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C23010011
Recombinant Histone H2AX-H2B dimers
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C23010013
Recombinant Histone H3.1 - H4 tetramers
Protein description
Histones are the main constituents of the protein part of chromosomes of eukaryotic cells. They are rich in the amino acids arginine and lysine and have been greatly conserved during evolution. Histones pack the DNA into tight masses of chromatin. Two core histones of each class H2A, H2B, H3 and H4 assemble and are wrapped by 146 base pairs of DNA to form one octameric nucleosome. Histone tails undergo numerous post-translational modifications, which either directly or indirectly alter chromatin structure to facilitate transcriptional activation or repression or other nuclear processes. The histone variant H2AX replaces conventional H2A in a subset of nucleosomes. H2AX plays a central role in DNA repair and chromosomal stability and is required for cell cycle progression arrest in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks.
Quality control
Figure 1.
SDS page of the Recombinant Histone H2A.X. The position of the protein of interest is indicated on the right; the marker (in kDa) is shown on the left.
Documents
| C23010005 histone H2AX DATASHEET C23010005 histone H2AX tds | Download |
Publications
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